Flutikason adalah senyawa glukokortikoid yang digunakan untuk mengobati gejala penyakit rongga hidung 1 2 3 4 5 Baik est

Flutikason adalah senyawa glukokortikoid yang digunakan untuk mengobati gejala penyakit rongga hidung. Baik esternya yakni flutikason propionat dan flutikason furoat, juga digunakan sebagai antiinflamasi topikal dan kortikosteroid inhalasi, dan lebih sering digunakan sebagai perbandingan.

Flutikason

Nama sistematis (IUPAC)
S-fluorometil (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihidroksi-10,13,16-trimetil-3-okso-6,7,8,11,12,14,15,16-oktahidrosiklopenta[a]fenantrena-17-karbotioat
Data klinis
Kat. kehamilan	?
Status hukum	OTC (CA)
Rute	Intranasal, inhalasi, Topikal
Data farmakokinetik
Bioavailabilitas	0.51% (Intranasal)
Ikatan protein	91.0%
Metabolisme	Intranasal Hati (CYP3A4-dimediasi)
Waktu paruh	10 jam
Ekskresi	Ginjal
Pengenal
Nomor CAS	90566-53-3^N
Kode ATC	D07AC17 R01AD08 R03BA05 R01AD58
PubChem	CID 5311101
Ligan IUPHAR	6699
DrugBank	DB00588
ChemSpider	4470631^Y
UNII	CUT2W21N7U^Y
KEGG	D07981^Y
ChEBI	CHEBI:5134^N
ChEMBL	CHEMBL1201396^N
Sinonim	6α,9α-Difluoro-11β,17α-dihidroksi-16α-metil-21-tia-21-fluorometilpregna-1,4-dien-3,20-diona; S-(Fluorometil)-6α,9α-difluoro-11β,17α-dihidroksi-16α-metil-3-oksoandrosta-1,4-diena-17β-karbotioat
Data kimia
Rumus	C₂₂H₂₇F₃O₄S
InChI InChI=1S/C22H27F3O4S/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-19(15,2)21(14,25)17(27)9-20(13,3)22(11,29)18(28)30-10-23/h4-5,7,11,13-14,16-17,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1^Y Key:MGNNYOODZCAHBA-GQKYHHCASA-N^Y

Obat ini ada dalam Daftar Obat Esensial Organisasi Kesehatan Dunia. Pada tahun 2021, obat ini merupakan obat ke-23 yang paling sering diresepkan di Amerika Serikat, dengan lebih dari 25 juta resep, meskipun obat ini juga dijual bebas.

Referensi sunting

Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. hlm. 574–. ISBN 978-1-4757-2085-3.
^ Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. hlm. 1337–. ISBN 978-3-88763-075-1.
^ Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. hlm. 124–. ISBN 978-94-011-4439-1.
^ "Fluticasone - FDA prescribing information, side effects and uses".
Briggs GG, Freeman RK, Yaffe SJ (2012). Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Lippincott Williams & Wilkins. hlm. 600. ISBN 978-1451153590.
Spratto GR, Woods AL (2012). Delmar Nurse's Drug Handbook 2012. Cengage Learning. hlm. 748. ISBN 978-1111310653.
World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533 . WHO/MHP/HPS/EML/2021.02.
. ClinCalc. Diarsipkan dari versi asli tanggal 15 January 2024. Diakses tanggal 14 January 2024.
"Fluticasone - Drug Usage Statistics". ClinCalc. Diakses tanggal 14 January 2024.
"Fluticasone Nasal Spray". Diakses tanggal 21 October 2022.

[Elks2014-1] Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. hlm. 574–. ISBN 978-1-4757-2085-3.

[IndexNominum2000-2] Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. hlm. 1337–. ISBN 978-3-88763-075-1.

[MortonHall2012-3] Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. hlm. 124–. ISBN 978-94-011-4439-1.

[Drugs.com-4] "Fluticasone - FDA prescribing information, side effects and uses".

[Briggs_et_al2012-5] Briggs GG, Freeman RK, Yaffe SJ (2012). Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Lippincott Williams & Wilkins. hlm. 600. ISBN 978-1451153590.

[SprattoWoods2012-6] Spratto GR, Woods AL (2012). Delmar Nurse's Drug Handbook 2012. Cengage Learning. hlm. 748. ISBN 978-1111310653.

[WHO22nd-7] World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533 . WHO/MHP/HPS/EML/2021.02.

[8] . ClinCalc. Diarsipkan dari versi asli tanggal 15 January 2024. Diakses tanggal 14 January 2024.

[9] "Fluticasone - Drug Usage Statistics". ClinCalc. Diakses tanggal 14 January 2024.

[10] "Fluticasone Nasal Spray". Diakses tanggal 21 October 2022.