Ergotamin adalah obat yang digunakan untuk meredakan atau mencegah migrain Obat ergotamin biasanya dapat ditemukan dalam

Ergotamin adalah obat yang digunakan untuk meredakan atau mencegah migrain. Obat ergotamin biasanya dapat ditemukan dalam produk obat yang dikombinasikan dengan kafein. Obat ergotamin merupakan vasokonstriktor agonis adrenergik selektif alfa-1.

Ergotamin


Nama sistematis (IUPAC)
(6aR,9R)-N-((2R,5S,10aS,10bS)-5-Benzyl-10b-hydroxy-2-methyl-3,6-dioxooctahydro-2H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl)-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
Data klinis
Nama dagang	Cafergot (with caffeine), Ergomar, others
AHFS/Drugs.com	monograph
Kat. kehamilan	X(US)
Status hukum	Harus dengan resep dokter (S4) (AU) Schedule VI (CA) POM (UK) ℞-only (US)
Rute	Oral
Data farmakokinetik
Bioavailabilitas	Intravenous: 100%, Intramuscular: 47%, Oral: <1% (Enhanced by co-administration of caffeine)
Metabolisme	Hepatic
Waktu paruh	2 hours
Ekskresi	90% biliary
Pengenal
Nomor CAS	113-15-5^Y
Kode ATC	N02CA02
PubChem	CID 8223
Ligan IUPHAR	149
DrugBank	DB00696
ChemSpider	7930^Y
UNII	PR834Q503T^Y
KEGG	D07906^Y
ChEBI	CHEBI:64318^N
ChEMBL	CHEMBL442^Y
Sinonim	2'-Methyl-5'α-benzyl-12'-hydroxy-3',6',18-trioxoergotaman; 9,10α-Dihydro-12'-hydroxy-2'-methyl-5'α-(phenylmethyl)ergotaman-3',6',18-trione
Data kimia
Rumus	C₃₃H₃₅N₅O₅
InChI InChI=1S/C33H35N5O5/c1-32(35-29(39)21-15-23-22-10-6-11-24-28(22)20(17-34-24)16-25(23)36(2)18-21)31(41)38-26(14-19-8-4-3-5-9-19)30(40)37-13-7-12-27(37)33(38,42)43-32/h3-6,8-11,15,17,21,25-27,34,42H,7,12-14,16,18H2,1-2H3,(H,35,39)/t21-,25-,26+,27+,32-,33+/m1/s1^Y Key:XCGSFFUVFURLIX-VFGNJEKYSA-N^Y

Referensi sunting

^ Sanders SW, Haering N, Mosberg H, Jaeger H (1986). "Pharmacokinetics of ergotamine in healthy volunteers following oral and rectal dosing". European Journal of Clinical Pharmacology. 30 (3): 331–334. doi:10.1007/BF00541538. PMID 3732370.
^ Tfelt-Hansen P, Johnson ES (1993). "Ergotamine". Dalam Olesen J, Tfelt-Hansen P, Welch KM. The Headaches. New York: Raven Press. hlm. 313–22.
Ibraheem JJ, Paalzow L, Tfelt-Hansen P (December 1983). "Low bioavailability of ergotamine tartrate after oral and rectal administration in migraine sufferers". British Journal of Clinical Pharmacology. 16 (6): 695–699. doi:10.1111/j.1365-2125.1983.tb02243.x. PMC 1428366 . PMID 6419759.
"Ergotamine-Caffeine Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD". www.webmd.com (dalam bahasa Inggris). Diakses tanggal 2023-06-20.
"Ergotamine". go.drugbank.com. Diakses tanggal 2023-06-20.

Artikel bertopik farmasi ini adalah sebuah rintisan. Anda dapat membantu Wikipedia dengan mengembangkannya.

[kinetics1-1] Sanders SW, Haering N, Mosberg H, Jaeger H (1986). "Pharmacokinetics of ergotamine in healthy volunteers following oral and rectal dosing". European Journal of Clinical Pharmacology. 30 (3): 331–334. doi:10.1007/BF00541538. PMID 3732370.

[kinetics2-2] Tfelt-Hansen P, Johnson ES (1993). "Ergotamine". Dalam Olesen J, Tfelt-Hansen P, Welch KM. The Headaches. New York: Raven Press. hlm. 313–22.

[pmid6419759-3] Ibraheem JJ, Paalzow L, Tfelt-Hansen P (December 1983). "Low bioavailability of ergotamine tartrate after oral and rectal administration in migraine sufferers". British Journal of Clinical Pharmacology. 16 (6): 695–699. doi:10.1111/j.1365-2125.1983.tb02243.x. PMC 1428366 . PMID 6419759.

[4] "Ergotamine-Caffeine Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD". www.webmd.com (dalam bahasa Inggris). Diakses tanggal 2023-06-20.

[5] "Ergotamine". go.drugbank.com. Diakses tanggal 2023-06-20.