Eukaryotic translation initiation factor 2 alpha kinase 4 adalah enzim yang disandikan oleh gen EIF2AK4 dalam tubuh manusia 4 5 EIF2AK4Struktur yang tersediaPDBPencarian Ortolog PDBe RCSBDaftar kode id PDB1UKX 4OTNPengidentifikasiAliasEIF2AK4 GCN2 PVOD2 eukaryotic translation initiation factor 2 alpha kinase 4ID eksternalOMIM 609280 MGI 1353427 HomoloGene 40891 GeneCards EIF2AK4Lokasi gen Tikus Kr Kromosom 2 tikus 1 Pita2 2 E5Awal118 219 099 bp 1 Akhir118 305 715 bp 1 Ontologi genFungsi molekuler transferase activity nucleotide binding protein kinase activity tRNA binding kinase activity protein serine threonine kinase activity RNA binding ATP binding eukaryotic translation initiation factor 2alpha kinase activityKomponen seluler sitoplasma polysome cytosolic ribosomeProses biologis positive regulation of translational initiation in response to starvation adaptive immune response negative regulation of neuron differentiation positive regulation of long term synaptic potentiation positive regulation of adaptive immune response negative regulation of translational initiation in response to stress negative regulation of translational initiation Fosforilasi immune system process cellular response to UV cellular response to amino acid starvation negative regulation of CREB transcription factor activity regulation of feeding behavior belajar perkembangan sistem saraf viral translation neuron projection extension protein phosphorylation cellular response to cold long term memory defense response to virus cellular response to leucine starvation eiF2alpha phosphorylation in response to endoplasmic reticulum stress induction by virus of host autophagy protein autophosphorylation Siklus sel negative regulation by host of viral genome replication GO 0022415 viral process regulation of translation regulation of translational initiation positive regulation of defense response to virus by host T cell activation involved in immune response DNA damage checkpoint signaling regulation of translational initiation by eIF2 alpha phosphorylationSumber Amigo QuickGOOrtologSpesiesManusiaTikusEntrez44027527103EnsemblENSG00000128829ENSMUSG00000005102UniProtQ9P2K8Q9QZ05RefSeq mRNA NM 001013703NM 001177806NM 013719NM 001355383RefSeq protein NP 001013725NP 001171277NP 038747NP 001342312Lokasi UCSC n aChr 2 118 22 118 31 MbPencarian PubMed 2 3 WikidataLihat Sunting ManusiaLihat Sunting TikusDalam kedokteran suntingMutasi pada gen ini dapat memicu hipertensi paru 6 Referensi sunting a b c GRCm38 Ensembl release 89 ENSMUSG00000005102 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Berlanga JJ Santoyo J De Haro C Nov 1999 Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase Eur J Biochem 265 2 754 62 doi 10 1046 j 1432 1327 1999 00780 x PMID 10504407 Entrez Gene EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 Eyries M Montani D Girerd B et al EIF2AK4 mutations cause pulmonary veno occlusive disease a recessive form of pulmonary hypertension Nat Genet 2014 46 65 69 nbsp Artikel bertopik gen ini adalah sebuah rintisan Anda dapat membantu Wikipedia dengan mengembangkannya lbs Diperoleh dari https id wikipedia org w index php title EIF2AK4 amp oldid 22936750
