Triazavirin TZV Riamilovir adalah antivirus analog nukleotida yang awalnya dikembangkan di Rusia yang telah menunjukkan

Triazavirin (TZV, Riamilovir) adalah antivirus analog nukleotida yang awalnya dikembangkan di Rusia yang telah menunjukkan kemanjuran terhadap influenza A dan B, termasuk strain H5N1. Menurut riset, Triazavirin tampaknya mampu mengurangi dampak dari penyakit flu dan juga komplikasi penyakit terkait. Antivirus ini memiliki inti dari novel triazolotriazine, yang mewakili kelas struktural baru dari obat-obatan antivirus non-nukleosida.

Triazavirin

Nama sistematis (IUPAC)
2-methylsulfanyl-6-nitro[1,2,4]triazolo[5,1-c][1,2,4]triazin-7(4H)-one
Data klinis
Kat. kehamilan	?
Status hukum	? (US)
Pengenal
Nomor CAS	928659-17-0^Y
Kode ATC	?
PubChem	CID 3113817
ChemSpider	2367718
Data kimia
Rumus	C₅H₄N₆O₃S
Massa mol.	228.189
SMILES	eMolecules & PubChem
InChI InChI=1S/C5H4N6O3S/c1-15-5-6-4-8-7-2(11(13)14)3(12)10(4)9-5/h1H3,(H,6,8,9) Key:IDVQGNMSSHPZSJ-UHFFFAOYSA-N

Manfaat sunting

Triazavirin pada mulanya dikembangkan di Akademi Ilmu Pengetahuan Rusia, Universitas Federal Ural di Ekaterinburg, Rusia yang dikembangkan untuk mengatasi wabah dari virus Flu Burung (H5N1), kemudian dikarenakan terdapat beberapa persamaan dengan koronavirus, maka para peneliti merasa perlu untuk mencoba meneliti khasiat obatnya pada pasien korona. Sebagian besar penelitian dilakukan dalam rangka menguji aktivitas anti-infuenza.

Referensi sunting

Kiselev, O. I.; Deeva, E. G.; Mel'nikova, T. I.; Kozeletskaia, K. N.; Kiselev, A. S.; Rusinov, V. L.; Charushin, V. N.; Chupakhin, O. N. (2012-11). "[A new antiviral drug Triazavirin: results of phase II clinical trial]". Voprosy Virusologii. 57 (6): 9–12. ISSN 0507-4088. PMID 23477247.
Vincent, Martin J.; Bergeron, Eric; Benjannet, Suzanne; Erickson, Bobbie R.; Rollin, Pierre E.; Ksiazek, Thomas G.; Seidah, Nabil G.; Nichol, Stuart T. (2005-08-22). "Chloroquine is a potent inhibitor of SARS coronavirus infection and spread". Virology Journal. 2: 69. doi:10.1186/1743-422X-2-69. ISSN 1743-422X. PMC 1232869 . PMID 16115318.
Karpenko, Inna; Deev, Sergey; Kiselev, Oleg; Charushin, Valerey; Rusinov, Vladimir; Ulomsky, Eugeney; Deeva, Ella; Yanvarev, Dmitry; Ivanov, Alexander (2010-05). "Antiviral properties, metabolism, and pharmacokinetics of a novel azolo-1,2,4-triazine-derived inhibitor of influenza A and B virus replication". Antimicrobial Agents and Chemotherapy. 54 (5): 2017–2022. doi:10.1128/AAC.01186-09. ISSN 1098-6596. PMC 2863629 . PMID 20194696.
Shvetsov, Alexey V.; Zabrodskaya, Yana A.; Nekrasov, Peter A.; Egorov, Vladimir V. (2018-07-27). "Triazavirine supramolecular complexes as modifiers of the peptide oligomeric structure". Journal of Biomolecular Structure and Dynamics. 36 (10): 2694–2698. doi:10.1080/07391102.2017.1367329. ISSN 0739-1102. PMID 28828928.
"China tests Russian anti-viral drug which might treat coronavirus as Moscow warns of possible 'mass outbreak'". RT International (dalam bahasa Inggris). Diakses tanggal 2020-04-20.
^ Rusinov, Vladimir L.; Sapozhnikova, Irina M.; Ulomskii, Evgeny N.; Medvedeva, Natalia R.; Egorov, Vladimir V.; Kiselev, Oleg I.; Deeva, Ella G.; Vasin, Andrey V.; Chupakhin, Oleg N. (2015-03-01). "Nucleophilic substitution of nitro group in nitrotriazolotriazines as a model of potential interaction with cysteine-containing proteins". Chemistry of Heterocyclic Compounds (dalam bahasa Inggris). 51 (3): 275–280. doi:10.1007/s10593-015-1695-4. ISSN 1573-8353.
^ Loginova SIa, Borisevich SV, Maksimov VA, et al. Antibiot Khimioter. 2007;52(11-12):18‐20.
^ SIa, Loginova; Sv, Borisevich; Va, Maksimov; Vp, Bondarev; Sk, Kotovskaia; Vl, Rusinov; Vn, Charushin (2007). "[Investigation of Triazavirin Antiviral Activity Against Influenza A Virus (H5N1) in Cell Culture]". Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] (dalam bahasa Inggris). PMID 19275052. Diakses tanggal 2020-05-03.

[1] Kiselev, O. I.; Deeva, E. G.; Mel'nikova, T. I.; Kozeletskaia, K. N.; Kiselev, A. S.; Rusinov, V. L.; Charushin, V. N.; Chupakhin, O. N. (2012-11). "[A new antiviral drug Triazavirin: results of phase II clinical trial]". Voprosy Virusologii. 57 (6): 9–12. ISSN 0507-4088. PMID 23477247.

[2] Vincent, Martin J.; Bergeron, Eric; Benjannet, Suzanne; Erickson, Bobbie R.; Rollin, Pierre E.; Ksiazek, Thomas G.; Seidah, Nabil G.; Nichol, Stuart T. (2005-08-22). "Chloroquine is a potent inhibitor of SARS coronavirus infection and spread". Virology Journal. 2: 69. doi:10.1186/1743-422X-2-69. ISSN 1743-422X. PMC 1232869 . PMID 16115318.

[3] Karpenko, Inna; Deev, Sergey; Kiselev, Oleg; Charushin, Valerey; Rusinov, Vladimir; Ulomsky, Eugeney; Deeva, Ella; Yanvarev, Dmitry; Ivanov, Alexander (2010-05). "Antiviral properties, metabolism, and pharmacokinetics of a novel azolo-1,2,4-triazine-derived inhibitor of influenza A and B virus replication". Antimicrobial Agents and Chemotherapy. 54 (5): 2017–2022. doi:10.1128/AAC.01186-09. ISSN 1098-6596. PMC 2863629 . PMID 20194696.

[4] Shvetsov, Alexey V.; Zabrodskaya, Yana A.; Nekrasov, Peter A.; Egorov, Vladimir V. (2018-07-27). "Triazavirine supramolecular complexes as modifiers of the peptide oligomeric structure". Journal of Biomolecular Structure and Dynamics. 36 (10): 2694–2698. doi:10.1080/07391102.2017.1367329. ISSN 0739-1102. PMID 28828928.

[5] "China tests Russian anti-viral drug which might treat coronavirus as Moscow warns of possible 'mass outbreak'". RT International (dalam bahasa Inggris). Diakses tanggal 2020-04-20.

[:0-6] Rusinov, Vladimir L.; Sapozhnikova, Irina M.; Ulomskii, Evgeny N.; Medvedeva, Natalia R.; Egorov, Vladimir V.; Kiselev, Oleg I.; Deeva, Ella G.; Vasin, Andrey V.; Chupakhin, Oleg N. (2015-03-01). "Nucleophilic substitution of nitro group in nitrotriazolotriazines as a model of potential interaction with cysteine-containing proteins". Chemistry of Heterocyclic Compounds (dalam bahasa Inggris). 51 (3): 275–280. doi:10.1007/s10593-015-1695-4. ISSN 1573-8353.

[loginova-7] Loginova SIa, Borisevich SV, Maksimov VA, et al. Antibiot Khimioter. 2007;52(11-12):18‐20.

[:1-8] SIa, Loginova; Sv, Borisevich; Va, Maksimov; Vp, Bondarev; Sk, Kotovskaia; Vl, Rusinov; Vn, Charushin (2007). "[Investigation of Triazavirin Antiviral Activity Against Influenza A Virus (H5N1) in Cell Culture]". Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] (dalam bahasa Inggris). PMID 19275052. Diakses tanggal 2020-05-03.