Cuyuni-Mazaruni merupakan sebuah region di Guyana. Region ini terletak di bagian barat negara itu. Ibu kotanya ialah Bartica. Region ini memiliki luas wilayah 47.213 km² dengan memiliki jumlah penduduk 17.597 jiwa (2002).
Komunitas sunting
- Ajimipepai
- Akar (Akar Village)
- Amamure Village (Amamuri Village)
- Amokokopai Village
- Apanachi
- Arau Village
- Arawai Village
- Arimu Mine
- Assura Village
- Aunama (Aunama Village)
- Aurora
- Awarabati
- Barakara
- Bartica (Barteke)
- Butakari (Butukari)
- Ekereku
- Enachu (Enachu Landing, Enachu Station)
- Golden Grove
- Hororabo
- Imbaimadai
- Issano
- Isseneru
- Kaikan
- Kalacoon (Kalakoon House, Kalakun, Kalkoon)
- Kamarang
- Kamaria
- Kamikusa
- Kamuda (Kamuda Village)
- Kartuni
- Kaywaek (Kaywaek Village)
- Keweigek
- Klip
- Kokadai
- Kowaeng (Kowaeng Village)
- Kurachi
- Kurutuku Village
- Kwiokrebaru
- Lower Kamaria
- Meruwang
- Minata
- Mongreppo
- Morowta
- Muriakundi (Muruakundi)
- Muruwawe Village
- Opadai
- Oranapai (Oranapai Landing, Oranopai)
- Paruima (Paruima Mission)
- Pathawaru
- Peters Mine
- Pipillipai
- Poterima
- Saint Edwards Mission
- Saint Marys
- The Clip
- Tumereng (Tumareng, Tumureng)
- Upper Kamaria
- Waioklepalul (Waioklepaluta Village)
- Waramadan (Waramadon Village)
- Wineperu
- Wolga